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ATR-101 free base

CAS No. 133825-80-6

ATR-101 free base ( ATR101;Nevanimibe;PD-132301 )

Catalog No. M11356 CAS No. 133825-80-6

ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ATR-101 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis.
  • Description
    ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.Cushing Disease Phase 2 Clinical
  • Synonyms
    ATR101;Nevanimibe;PD-132301
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Endocrinology
  • Indication
    Cushing Disease

Chemical Information

  • CAS Number
    133825-80-6
  • Formula Weight
    421.63
  • Molecular Formula
    C27H39N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C
  • Chemical Name
    1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. LaPensee CR, et al. Endocrinology. 2016 May;157(5):1775-88.
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
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