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ATR-101 free base
CAS No. 133825-80-6
ATR-101 free base ( ATR101;Nevanimibe;PD-132301 )
Catalog No. M11356 CAS No. 133825-80-6
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameATR-101 free base
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NoteResearch use only, not for human use.
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Brief DescriptionATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis.
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DescriptionATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.Cushing Disease Phase 2 Clinical
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SynonymsATR101;Nevanimibe;PD-132301
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaEndocrinology
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IndicationCushing Disease
Chemical Information
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CAS Number133825-80-6
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Formula Weight421.63
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Molecular FormulaC27H39N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C
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Chemical Name1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. LaPensee CR, et al. Endocrinology. 2016 May;157(5):1775-88.
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
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